Lack of association between the HLA region RS7775055 polymorphism and JIA in patients from russia
نویسندگان
چکیده
Introduction Juvenile idiopathic arthritis (JIA) refers to a group of conditions involving joint inflammation that first appears before the age of 16. Juvenile idiopathic arthritis is thought to arise from a combination of genetic and environmental factors. Numerous associations between HLA polymorphisms and JIA subtypes have been reported in multiple populations. The HLA region SNP rs7775055 is a part of the HLA-DRB1*0801–HLADQA1*0401–HLA-DQB1*0402 haplotype, which has been shown to increase risk of JIA in UK and non-Hispanic Caucasians US patients. The recent study of Hinks and co-authors also showed the strong evidence of association between rs7775055 and JIA (odds ratio (OR) = 6.01; p=3.14×10) in patients from across the US, UK and Germany.
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